The 2-Minute Rule for cees dekker
The 2-Minute Rule for cees dekker
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Nanotechnology features An array of possibilities to lead to biology. Listed here I'll current illustrations wherever nanofabrication – a chance to make confined buildings with dimensions at will – is utilised to examine the biophysics of solitary molecules and cells. I will current some examples from our lab:
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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters
2015, discovery that condensin is a really adaptable protein construction; and very first detection of DNA knots utilizing nanopores
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry
Due to the fact 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling reports of nucleosomes and DNA repair proteins to DNA translocation as a result of nanopores. Recently his investigation has centered on learning mobile division with microbes on chip, while his ultimate interest is in the route of knowing artificial cells.
He also found time to put in writing several textbooks, send Virtually forty thousand https://www.ceesdekker.net tweets and guide a successful exploration group at Delft University of Technology. ‘It doesn’t come to feel like work’, he claims. ‘I’m just terribly curious.’
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Resolving the step size in condensin-pushed DNA loop extrusion identifies ATP binding given that the move-generating process
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is shown in gray, the rim with the pore is highlighted in purple, as well as a 3D rendering from the motion of your DNA rod is exhibited.
1999, to start with measurement on the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
Developments in nanotechnology from the nineteen nineties designed setting up Digital equipment from solitary molecules a likelihood. Cees Dekker recounts how his crew designed a place-temperature transistor based upon one carbon nanotube.
2004, discovery of new physics in translocation of DNA as a result of nanopores; 1st experimental research of ions conduction in nanofluidic channels; to start with electrochemistry with specific single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; very first electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of the mechanical Houses of double-stranded RNA; and initial one-molecule research of DNA translocation by a restriction-modification enzyme.